hrp0089p2-p383 | Thyroid P2 | ESPE2018

A Successful Switch Experience from High-dose PTU to MMI on Day 4 of Graves’ Thyroid Storm in a 14-Year-Old Girl

Shinohara Hiroyuki , Iwabuchi Atsushi , Yamada Akiko , Kai Tomomi , Kamoda Tomohiro

Background: The standard pharmacological treatment strategy of thyroid storm according to 2016 Japan Society of Pediatric Endocrinology Guideline. Although thiamazole (MMI) is recommended be used as the first choice in GravesÂ’ disease, the effect of propylthiouracil (PTU) to block the conversion from T4 to T3 in peripheral tissues encourages clinicians to use against thyroid storm in its very early phase, and switch to MMI later. Nevertheless, the optimal timing of the sw...